RWJ-671818

RWJ-671818 is an orally active inhibitor of human α-thrombin with a Ki of 1.3 nM. RWJ-671818 can be studied in research on venous and arterial thrombosis[1].

Product Specifications

CAS Number

[252271-49-1]

UNSPSC

12352005

Target

Thrombin

Related Pathways

Metabolic Enzyme/Protease

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Smiles

O=C(CN1C(C(NCC(F)(C2=CC=CC=C2)F)=NC=C1C)=O)NCCONC(N)=N

Molecular Formula

C18H23F2N7O3

Molecular Weight

423.42

References & Citations

[1]Lu, T., et al., (2010) . Discovery and clinical evaluation of 1-{N-[2- (amidinoaminooxy) ethyl]amino}carbonylmethyl-6-methyl-3-[2,2-difluoro-2-phenylethylamino]pyrazinone (RWJ-671818), a thrombin inhibitor with an oxyguanidine P1 motif. Journal of medicinal chemistry, 53 (4), 1843-1856.