RWJ-671818
RWJ-671818 is an orally active inhibitor of human α-thrombin with a Ki of 1.3 nM. RWJ-671818 can be studied in research on venous and arterial thrombosis[1].
Product Specifications
CAS Number
252271-49-1
UNSPSC
12352005
Target
Thrombin
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Smiles
O=C(CN1C(C(NCC(F)(C2=CC=CC=C2)F)=NC=C1C)=O)NCCONC(N)=N
Molecular Formula
C18H23F2N7O3
Molecular Weight
423.42
References & Citations
[1]Lu, T., et al., (2010) . Discovery and clinical evaluation of 1-{N-[2- (amidinoaminooxy) ethyl]amino}carbonylmethyl-6-methyl-3-[2,2-difluoro-2-phenylethylamino]pyrazinone (RWJ-671818), a thrombin inhibitor with an oxyguanidine P1 motif. Journal of medicinal chemistry, 53 (4), 1843-1856.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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