Auristatin S

Auristatin S is an Auristatin payload with potent antitumor activity. Auristatin S attenuates bystander activity with improved off-target toxicity. Auristatin S has excellent tolerability in Karpas/KarpasBVR cell models. Auristatin S can be used as a cytotoxic component of antibody-drug conjugates (ADCs) to treat several different cancer types[1].

Product Specifications

CAS Number

[3028453-70-2]

UNSPSC

12352005

Target

ADC Payload; Microtubule/Tubulin

Related Pathways

Antibody-drug Conjugate/ADC Related; Cell Cycle/DNA Damage; Cytoskeleton

Field of Research

Cancer

Smiles

CC[C@@H]([C@H](N(C([C@H](C(C)C)NC([C@H](CO)N(C)C)=O)=O)C)[C@H](OC)CC(N1CCC[C@H]1[C@@H]([C@@H](C)C(N[C@@H](CC2=CC=CC=C2)CO)=O)OC)=O)C

Molecular Formula

C38H65N5O8

Molecular Weight

719.95

References & Citations

[1]Moquist PN, et al. Auristatin S: An Auristatin Payload with Improved Tolerability and Modified Bystander Activity. ACS Med Chem Lett. 2025 Jun 23;16 (7) :1354-1358.