Pipobroman (Standard)
Pipobroman (Standard) is the analytical standard of Pipobroman. This product is intended for research and analytical applications. Pipobroman is a bromide derivative of piperazine and acts as an alkylating agent. Pipobroman plays its role by inhibiting DNA and RNA polymerase or by reducing pyrimidine nucleotide incorporation into DNA. Pipobroman can be used for the cancer research, including polycythemia vera, myeloproliferative neoplasm, and AML et.al[1].
Product Specifications
CAS Number
54-91-1
UNSPSC
12352100
Target
DNA Alkylator/Crosslinker; DNA/RNA Synthesis; Reference Standards
Related Pathways
Cell Cycle/DNA Damage; Others
Field of Research
Cancer
Smiles
O=C(N1CCN(C(CCBr)=O)CC1)CCBr
Molecular Formula
C10H16Br2N2O2
Molecular Weight
356.05
References & Citations
[1]Jean-Jacques Kiladjian, et al. Treatment of polycythemia vera with hydroxyurea and pipobroman: final results of a randomized trial initiated in 1980. J Clin Oncol. 2011 Oct 10;29 (29) :3907-13.|[2]Charles Cassius, et al. Association of Vemurafenib and Pipobroman Enhances BRAF-CRAF Dimerization in Squamous Cell Carcinoma. J Invest Dermatol. 2016 Jun;136 (6) :1302-1305.|[3]Yellin TO. Effects of piposulfan (Ancyte) on protein and DNA synthesis in Ehrlich ascites carcinoma. Life Sci II. 1971 Jun 8;10 (11) :605-12.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
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