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Phenformin (Standard)

Phenformin (Standard) is the analytical standard of Phenformin. This product is intended for research and analytical applications. Phenformin (1-phenethylbiguanide) is an orally active antidiabetic and anticancer agent. Phenformin has an incidence of associated lactic acidosis. Phenformin acts through acting AMPK activation and blocking mTOR pathway. Phenformin is also a substrate of P-glycoprotein (P-gp), and an OXPHOS inhibitor. Phenformin induces cancer cell apoptosis[1][2].

Product Specifications

CAS Number

114-86-3

UNSPSC

12352100

Target

AMPK; Apoptosis; Mitochondrial Metabolism; Reference Standards

Related Pathways

Apoptosis; Epigenetics; Metabolic Enzyme/Protease; Others; PI3K/Akt/mTOR

Field of Research

Cancer; Metabolic Disease

Smiles

NC(NC(NCCC1=CC=CC=C1)=N)=N

Molecular Formula

C10H15N5

Molecular Weight

205.26

References & Citations

[1]García Rubiño ME, et al. Phenformin as an Anticancer Agent: Challenges and Prospects. Int J Mol Sci. 2019 Jul 5;20 (13) :3316.|[2]Yendapally R, et al. A review of phenformin, metformin, and imeglimin. Drug Dev Res. 2020 Jun;81 (4) :390-401.

Shipping Conditions

Room temperature

Scientific Category

Reference Standards

Available Sizes

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