PG-11047 (tetrahydrochloride)

PG-11047 (CGC-11047), a polyamine analogue, is a nonfunctional competitor of the natural polyamine spermine. PG-11047 has broad spectrum anticancer activities[1][2].

Product Specifications

CAS Number

[206991-64-2]

Product Name Alternative

CGC-11047 (tetrahydrochloride)

UNSPSC

12352211

Target

Drug Derivative

Related Pathways

Others

Applications

Cancer-programmed cell death

Field of Research

Cancer

Purity

95.0

Solubility

10 mM in DMSO|H2O : ≥ 30 mg/mL

Smiles

CCNCCCNC/C=C\CNCCCNCC.[H]Cl.[H]Cl.[H]Cl.[H]Cl

Molecular Formula

C14H36Cl4N4

Molecular Weight

402.27

References & Citations

[1]Wen-Lin Kuo, et al. A systems analysis of the chemosensitivity of breast cancer cells to the polyamine analogue PG-11047. BMC Med. 2009 Dec 14;7:77.|[2]Murray Stewart T, et al. A Phase Ib multicenter, dose-escalation study of the polyamine analogue PG-11047 in combination with gemcitabine, docetaxel, bevacizumab, erlotinib, cisplatin, 5-fluorouracil, or sunitinib in patients with advanced solid tumors or lymphoma. Cancer Chemother Pharmacol. 2021 Jan;87 (1) :135-144.