17-Epiestriol-d5-1
17-Epiestriol-d5-1 is the deuterium labeled 17-Epiestriol (HY-163712) . 17-Epiestriol is an estrogen metabolite and a selective estrogen receptor (ER) β agonist. 17-epiestriol inhibits the mRNA and protein expression of the vascular cell adhesion molecule VCAM-1 induced by tumor necrosis factor α (TNFα) . 17-epiestriol also inhibits TNFα-induced VCAM-1 expression and prevents NF-κB migration to the nucleus. 17-Epiestriol also induces the mRNA and protein expression of endothelial nitric oxide synthase[1].
Product Specifications
CAS Number
[2734919-65-2]
UNSPSC
12352005
Target
Estrogen Receptor/ERR; Isotope-Labeled Compounds
Related Pathways
Others; Vitamin D Related/Nuclear Receptor
Field of Research
Endocrinology
Smiles
C[C@@]12[C@](C[C@H]([C@H]2O)O)([H])[C@@]3([H])[C@@](C([H])C1)([2H])C4=CC=C(O)C=C4C([2H])([2H])C3([2H])[2H]
Molecular Formula
C18H19D5O3
Molecular Weight
293.41
References & Citations
[1]17-Epiestriol, an Estrogen Metabolite, Is More Potent Than Estradiol in Inhibiting Vascular Cell Adhesion Molecule 1 (VCAM-1) mRNA Expression
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
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