Omtriptolide (sodium)
Omtriptolide sodium (PG490-88Na) is a derivative of Triptolide. Omtriptolide sodium exhibits significant immunosuppressive, anti-fibrotic and anti-inflammatory properties. The mechanism of action of Omtriptolide sodium is diverse, including inhibiting T cell activation and proliferation, inducing T cell apoptosis (apoptosis), blocking fibroblast maturation/proliferation, inhibiting TGF-β mRNA expression, and suppressing pro-inflammatory cytokines (such as IL-2, IFN-γ, TNF-α) by blocking transcription factors such as NF-κB. Omtriptolide sodium can be used for research on obstructive airway diseases, pulmonary fibrosis and graft-versus-host disease[1][2][3][4].
Product Specifications
CAS Number
195883-09-1
Product Name Alternative
PG 490-88Na
UNSPSC
12352005
Target
Apoptosis; IFNAR; Interleukin Related; NF-κB; TGF-β Receptor; TNF Receptor
Related Pathways
Apoptosis; Immunology/Inflammation; NF-κB; TGF-beta/Smad
Field of Research
Inflammation/Immunology
Smiles
O=C1OCC2=C1CC[C@@]3(C)[C@@]2([H])C[C@H]4[C@@]5(O4)[C@H](OC(CCC(O[Na])=O)=O)[C@]6(C(C)C)[C@@H](O6)[C@H]7[C@]53O7
Molecular Formula
C24H27NaO9
Molecular Weight
482.46
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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