GRP75-IN-1
GRP75-IN-1 (Compound 33) is an anti-endometrial cancer (EC) agent. GRP75-IN-1 induces apoptosis in endometrial cancer cells. GRP75-IN-1 hydrochloride reduces mitochondrial Ca2+ levels by targeting GRP75 and disrupting its interaction with IP3R. GRP75-IN-1 inhibits tumor growth in human endometrial cancer xenograft animal models. GRP75-IN-1 can be used for research in endometrial cancer[1].
Product Specifications
CAS Number
[2922680-16-6]
UNSPSC
12352005
Target
Apoptosis
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
CN1CCC2(CCN(CC2)CCCCCN3C4=C(SC5=CC=C(C=C53)OC)C=CC=N4)CC1
Molecular Formula
C27H38N4OS
Molecular Weight
466.68
References & Citations
[1]Ling X, et al. Discovery of Novel Azaphenothiazine Derivatives to Suppress Endometrial Cancer by Targeting GRP75 to Impair Its Interaction with IP3R and Mitochondrial Ca2+ Homeostasis. J Med Chem. 2024 Aug 22;67 (16) :13829-13851.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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