Nivocasan
Nivocasan (GS 9450; LB-84451) is a pan-caspase inhibitor that irreversibly arrests caspase-1 activity and inhibits that of caspase-8. Nivocasan inhibits IL-1β cleavage and blocks osteoclast differentiation. Nivocasan inhibits the protein expression of NFATc1 and CSTK[1].
Product Specifications
CAS Number
908253-63-4
Product Name Alternative
GS 9450; LB-84451
UNSPSC
12352005
Target
Caspase; Interleukin Related
Related Pathways
Apoptosis; Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Smiles
FC[C@@](O)(OC(C1)=O)[C@H]1NC([C@@]2(CC(C3=NC=CC4=C3C=CC=C4)=NO2)C(C)C)=O
Molecular Formula
C21H22FN3O5
Molecular Weight
415.41
References & Citations
[1]Kim HY, et al. Auranofin Inhibits RANKL-Induced Osteoclastogenesis by Suppressing Inhibitors of κB Kinase and Inflammasome-Mediated Interleukin-1β Secretion. Oxid Med Cell Longev. 2019 Apr 22;2019:3503912.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
Caspase 1; Caspase 8; IL-1
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