G9D-4 (TFA)
G9D-4 (TFA) is a potent PROTAC degrader of G9a, with the DC50 value of 0.1 μM in PANC-1 cells and do not directly perturb GLP protein, with the DC50 of > 10 μM. G9D-4 (TFA) plays an important role in pancreatic cancer research (Pink: Ligand for target protein G9a/GLP Inhibitor (HY-15273) ; Black: Linker; Blue: Ligand for E3 ligase (HY-10984) ) [1].
Product Specifications
UNSPSC
12352005
Target
Histone Methyltransferase; PROTACs
Related Pathways
Epigenetics; PROTAC
Field of Research
Cancer
Purity
99.44
Solubility
DMSO : 200 mg/mL (ultrasonic)
Smiles
COC1=CC2=C(C=C1OCCCN3CCCC3)N=C(C4CCCCC4)N=C2NC5CCN(CC5)CCCC(NCCCCCCCCCNC6=C(C7=CC=C6)C(N(C7=O)C8C(NC(CC8)=O)=O)=O)=O.OC(C(F)(F)F)=O
Molecular Formula
C55H76F3N9O9
Molecular Weight
1064.24
References & Citations
[1]Yunkai Shi, et al. Discovery of Potent and Selective G9a Degraders for the Treatment of Pancreatic Cancer. J Med Chem. 2024 Jul 23.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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