Epicochlioquinone A

Epicochlioquinone A can inhibit rat liver microsomal ACAT with IC50 of 1.7 μM, inhibit plasma lecithin cholesterol acyltransferase (LCAT) with IC50 of 15.8 μM, and inhibit cholesterol absorption in rats by 50% at 75 mg/kg[1].

Product Specifications

CAS Number

[147384-57-4]

UNSPSC

12352005

Target

Acyltransferase

Related Pathways

Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Smiles

C[C@@]12[C@]3([H])[C@@](OC4=C(C(C=C(C4=O)[C@H](C)[C@H](OC(C)=O)[C@@H](C)CC)=O)[C@H]3O)(CC[C@@]1([H])O[C@H](CC2)C(C)(O)C)C

Molecular Formula

C30H44O8

Molecular Weight

532.67

References & Citations

[1]T Fujioka, et al. Epi-cochlioquinone A, a novel acyl-CoA : cholesterol acyltransferase inhibitor produced by Stachybotrys bisbyi. J Antibiot (Tokyo) . 1996 May;49 (5) :409-13.