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(S) -JWZ-5-13

(S) -JWZ-5-13 (compound 17-Neg), a PROTAC CDK7 degrader, is a negative control compound of JWZ-5-13. (S) -JWZ-5-13 displays similar in vitro CDK7 inhibition (IC50 = 21.1 nM) to JWZ-5-13, but fails to induce CDK7 degradation in cells[1].

Product Specifications

UNSPSC

12352005

Target

CDK; PROTACs

Related Pathways

Cell Cycle/DNA Damage; PROTAC

Field of Research

Cancer

Smiles

O=C(NC1=NNC2=C1CN(C(N[C@@H](C3=CC=CC=C3)CN(C)C)=O)C2(C)C)C4=CC=C(C#CCCCC(N[C@@H](C(C)(C)C)C(N5C[C@@H](O)C[C@H]5C(N[C@@H](C)C6=CC=C(C7=C(C)N=CS7)C=C6)=O)=O)=O)C=C4

Molecular Formula

C54H66N10O6S

Molecular Weight

983.23

References & Citations

[1]Ji W, et al. Discovery of bivalent small molecule degraders of cyclin-dependent kinase 7 (CDK7) . Eur J Med Chem. 2024 Oct 5;276:116613.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

Phase 2

Isoform

CDK7

Available Sizes

Frequently Asked Questions

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