PBA-1105 (TFA)
PBA-1105 TFA is an autophagy-targeting chimera (AUTOTAC) that induces p62 self-oligomerization. PBA-1105 TFA selectively binds to exposed hydrophobic regions of misfolded proteins, facilitating their degradation via the autophagic pathway. PBA-1105 TFA increases the autophagic flux of Ub-conjugated aggregates[1].
Product Specifications
UNSPSC
12352005
Target
Autophagy; AUTOTACs
Related Pathways
Autophagy; PROTAC
Field of Research
Cancer; Neurological Disease
Purity
99.58
Smiles
O=C(O)C(F)(F)F.O=C(CCCC1=CC=CC=C1)NCCOCCOCCOCCNCC2=CC(OCC3=CC=CC=C3)=C(OCC4=CC=CC=C4)C=C2
Molecular Formula
C41H49F3N2O8
Molecular Weight
754.83
References & Citations
[1]Chang Hoon Ji, et al. The AUTOTAC chemical biology platform for targeted protein degradation via the autophagy-lysosome system. Nat Commun. 2022 Feb 16;13 (1) :904.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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