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BAY-593 (hydrochloride)

BAY-593 (hydrochloride) is an orally active GGTase-I inhibitor. BAY-593 (hydrochloride) can block YAP1/TAZ signaling in animals and has antitumor activity[1].

Product Specifications

CAS Number

2413020-57-0

UNSPSC

12352005

Target

GGTase; YAP

Related Pathways

Metabolic Enzyme/Protease; Stem Cell/Wnt

Field of Research

Cancer

Smiles

O=C(N1CCC2(CCNC[C@@]2([H])C3=CC=CC=C3OC)CC1)[C@@](OC)(C(F)(F)F)C4=CC=CC=C4.Cl

Molecular Formula

C26H32ClF3N2O3

Molecular Weight

512.99

References & Citations

[1]Graham K, et al. Discovery of YAP1/TAZ pathway inhibitors through phenotypic screening with potent anti-tumor activity via blockade of Rho-GTPase signaling. Cell Chem Biol. 2024 Mar 19:S2451-9456 (24) 00087-4.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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