Cilengitide (Standard)
Cilengitide (Standard) is the analytical standard of Cilengitide. This product is intended for research and analytical applications. Cilengitide (EMD 121974) is a potent integrins antagonist with IC50s of 0.61 nM (ανβ3), 8.4 nM (ανβ5) and 14.9 nM (α5β1), respectively. Cilengitide inhibits the binding of ανβ3 and ανβ5 to Vitronectin with IC50s of 4 nM and 79 nM, respectively. Cilengitide inhibits TGF-β/Smad signaling, mediates PD-L1 expression. Cilengitide also induces apoptosis, shows antiangiogenic effect in the research against glioblastoma and other cancers[1][2][3].
Product Specifications
CAS Number
[188968-51-6]
UNSPSC
12352100
Target
Apoptosis; Autophagy; Integrin; PD-1/PD-L1; Reference Standards; STAT
Related Pathways
Apoptosis; Autophagy; Cytoskeleton; Immunology/Inflammation; JAK/STAT Signaling; Others; Stem Cell/Wnt
Field of Research
Cancer
Smiles
O=C(NCC(N[C@H](C(N[C@H](CC1=CC=CC=C1)C(N([C@H]2C(C)C)C)=O)=O)CC(O)=O)=O)[C@H](CCCNC(N)=N)NC2=O
Molecular Formula
C27H40N8O7
Molecular Weight
588.66
References & Citations
Shipping Conditions
Room temperature
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-16141R/
Scientific Category
Reference Standards
Available Sizes
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