BMS-214662 (hydrochloride)
BMS-214662 hydrochloride is an inhibitor of farnesyltransferase (Farnesyl Transferase) . BMS-214662 hydrochloride can effectively block the localization and function of Ras proteins on the cell membrane by inhibiting the prenylation modification of Ras proteins, thereby exerting anti-tumor activity. The IC50 value of BMS-214662 hydrochloride for H-Ras is 1.3 nM, and for K-Ras it is 8.4 nM. BMS-214662 hydrochloride can be used in the research of tumor diseases related to Ras[1][2].
Product Specifications
CAS Number
195981-08-9
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H332, H335
Target
Farnesyl Transferase; Ras
Related Pathways
GPCR/G Protein; MAPK/ERK Pathway; Metabolic Enzyme/Protease
Field of Research
Cancer
Purity
98.54
Solubility
DMSO : ≥ 100 mg/mL
Smiles
N#CC1=CC=C(N(CC2=CN=CN2)C[C@@H](CC3=CC=CC=C3)N(S(=O)(C4=CC=CS4)=O)C5)C5=C1.Cl
Molecular Formula
C25H24ClN5O2S2
Molecular Weight
526.07
Precautions
H302, H315, H319, H332, H335
References & Citations
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
Phase 1
Available Sizes
Frequently Asked Questions
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