BMS-214662 (hydrochloride)

BMS-214662 hydrochloride is an inhibitor of farnesyltransferase (Farnesyl Transferase) . BMS-214662 hydrochloride can effectively block the localization and function of Ras proteins on the cell membrane by inhibiting the prenylation modification of Ras proteins, thereby exerting anti-tumor activity. The IC50 value of BMS-214662 hydrochloride for H-Ras is 1.3 nM, and for K-Ras it is 8.4 nM. BMS-214662 hydrochloride can be used in the research of tumor diseases related to Ras[1][2].

Product Specifications

CAS Number

[195981-08-9]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H332, H335

Target

Farnesyl Transferase; Ras

Related Pathways

GPCR/G Protein; MAPK/ERK Pathway; Metabolic Enzyme/Protease

Field of Research

Cancer

Purity

98.54

Solubility

DMSO : ≥ 100 mg/mL

Smiles

N#CC1=CC=C(N(CC2=CN=CN2)C[C@@H](CC3=CC=CC=C3)N(S(=O)(C4=CC=CS4)=O)C5)C5=C1.Cl

Molecular Formula

C25H24ClN5O2S2

Molecular Weight

526.07

Precautions

H302, H315, H319, H332, H335

References & Citations

[1]Hunt JT, et al. Discovery of (R) -7-cyano-2,3,4, 5-tetrahydro-1- (1H-imidazol-4-ylmethyl) -3- (phenylmethyl) -4- (2-thienylsulfonyl) -1H-1,4-benzodiazepine (BMS-214662), a farnesyltransferase inhibitor with potent preclinical antitumor activity. J Med Chem. 2000 Oct 5;43 (20) :3587-95.|[2]Rose WC, et al. Preclinical antitumor activity of BMS-214662, a highly apoptotic and novel farnesyltransferase inhibitor. Cancer Res. 2001 Oct 15;61 (20) :7507-17.