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Spire2-FMN2 PPI-IN-1 (dihydrochloride)

Spire2/FMN2 PPI-IN-1 (Compound 13) dihydrochloride is a selective inhibitory fragment targeting the Spire2-FMN2 interaction, with an IC50 of 62 μM. Spire2/FMN2 PPI-IN-1 dihydrochloride has affinity for KIND2, with a Kd of 87.7 μM, and does not inhibit KIND1. Spire2/FMN2 PPI-IN-1 dihydrochloride can be used for the development of chemical probes for the Spire2-FMN2 interaction[1].

Product Specifications

UNSPSC

12352005

Target

Arp2/3 Complex

Related Pathways

Cytoskeleton

Field of Research

Others

Purity

98.99

Smiles

FC1=CC=C2C(N=CC=C2NCCN)=C1.Cl.Cl

Molecular Formula

C11H14Cl2FN3

Molecular Weight

278.15

References & Citations

[1]Radoslaw Kitel, et al. Discovery of Inhibitory Fragments That Selectively Target Spire2-FMN2 Interaction. J Med Chem. 2023 Dec 14;66 (23) :15715-15727.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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