Spire2-FMN2 PPI-IN-1 (dihydrochloride)
Spire2/FMN2 PPI-IN-1 (Compound 13) dihydrochloride is a selective inhibitory fragment targeting the Spire2-FMN2 interaction, with an IC50 of 62 μM. Spire2/FMN2 PPI-IN-1 dihydrochloride has affinity for KIND2, with a Kd of 87.7 μM, and does not inhibit KIND1. Spire2/FMN2 PPI-IN-1 dihydrochloride can be used for the development of chemical probes for the Spire2-FMN2 interaction[1].
Product Specifications
UNSPSC
12352005
Target
Arp2/3 Complex
Related Pathways
Cytoskeleton
Field of Research
Others
Purity
98.99
Smiles
FC1=CC=C2C(N=CC=C2NCCN)=C1.Cl.Cl
Molecular Formula
C11H14Cl2FN3
Molecular Weight
278.15
References & Citations
[1]Radoslaw Kitel, et al. Discovery of Inhibitory Fragments That Selectively Target Spire2-FMN2 Interaction. J Med Chem. 2023 Dec 14;66 (23) :15715-15727.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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