Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

Z218484536

Z218484536 is a selective and brain-penetrant phosphoserine phosphatase (PSPH) inhibitor. Z218484536 binds to PSPH with a Kd value of approximately 0.23 μM. Z218484536 reduces L-serine and D-serine levels in astrocytes. Z218484536 is able to suppress spontaneous epileptic seizures without causing serious side effects. Z218484536 also shows good anti-epileptic effects in the temporal lobe epilepsy (TLE) model[1].

Product Specifications

CAS Number

1223877-07-3

UNSPSC

12352005

Target

Phosphatase

Related Pathways

Metabolic Enzyme/Protease

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Concentration

10mM

Purity

97.65

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(N/N=C/C1=CNN=C1C2=CC=C(F)C=C2)N

Molecular Formula

C11H10FN5O

Molecular Weight

247.23

References & Citations

[1]Sha L, et al. Pharmacological inhibition of PSPH reduces serine levels and epileptic seizures. Nat Chem Biol. 2025 Jun 2.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

More Discoveries

Explore Other Products

Browse additional items from our catalog

Tissue Protein Lysate, Kidney
CP500880 150 µg

Tissue Protein Lysate, Kidney

Sign In for Pricing
View Details
HB EGF (HBEGF) Mouse Monoclonal Antibody [Clone ID: OTI6F4]
CF812466 100 µg

HB EGF (HBEGF) Mouse Monoclonal Antibody [Clone ID: OTI6F4]

Sign In for Pricing
View Details
Frozen Tissue Sections, Colon
CS502527 5x 5 µm

Frozen Tissue Sections, Colon

Sign In for Pricing
View Details
IGF2BP1 Human Gene Knockout Kit (CRISPR)
KN216226 1 Kit

IGF2BP1 Human Gene Knockout Kit (CRISPR)

Sign In for Pricing
View Details
PYK2 (Ab-580) Antibody
8B0084-AAT 50 µg

PYK2 (Ab-580) Antibody

Sign In for Pricing
View Details
Anti-HA (YPYDVPDYA) FAST IP kit
EA-IP-K002 50 Tests

Anti-HA (YPYDVPDYA) FAST IP kit

Sign In for Pricing
View Details