Z218484536
Z218484536 is a selective and brain-penetrant phosphoserine phosphatase (PSPH) inhibitor. Z218484536 binds to PSPH with a Kd value of approximately 0.23 μM. Z218484536 reduces L-serine and D-serine levels in astrocytes. Z218484536 is able to suppress spontaneous epileptic seizures without causing serious side effects. Z218484536 also shows good anti-epileptic effects in the temporal lobe epilepsy (TLE) model[1].
Product Specifications
CAS Number
[1223877-07-3]
UNSPSC
12352005
Target
Phosphatase
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Concentration
10mM
Purity
97.65
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(N/N=C/C1=CNN=C1C2=CC=C(F)C=C2)N
Molecular Formula
C11H10FN5O
Molecular Weight
247.23
References & Citations
[1]Sha L, et al. Pharmacological inhibition of PSPH reduces serine levels and epileptic seizures. Nat Chem Biol. 2025 Jun 2.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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