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HPK1-IN-46

HPK1-IN-46 (Compound 36) is an efficient and highly selective HPK1 reverse indazole inhibitor with an IC50 value of 1.1 nM. HPK1-IN-46 exhibits high selectivity for CDK2, JAK1, and JAK2. HPK1-IN-46 inhibits SLP76 phosphorylation mediated by HPK1, reverses T-cell inhibition, and enhances anti-tumor immunity. HPK1-IN-46 can be used in immunotherapy research for tumors[1].

Product Specifications

CAS Number

2810880-82-9

UNSPSC

12352005

Target

MAP4K

Related Pathways

MAPK/ERK Pathway

Field of Research

Cancer

Smiles

FC1=CC=CC(OC)=C1C2=CC3=C(C=NN3C4=CC=CC(N5CC6N(C(CC6)C5)C)=N4)C=N2

Molecular Formula

C25H25FN6O

Molecular Weight

444.50

References & Citations

[1]Yu EC, et al. Identification of Potent Reverse Indazole Inhibitors for HPK1. ACS Med Chem Lett. 2021 Mar 1;12 (3) :459-466.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

MAP4K1/HPK1

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