HPK1-IN-46
HPK1-IN-46 (Compound 36) is an efficient and highly selective HPK1 reverse indazole inhibitor with an IC50 value of 1.1 nM. HPK1-IN-46 exhibits high selectivity for CDK2, JAK1, and JAK2. HPK1-IN-46 inhibits SLP76 phosphorylation mediated by HPK1, reverses T-cell inhibition, and enhances anti-tumor immunity. HPK1-IN-46 can be used in immunotherapy research for tumors[1].
Product Specifications
CAS Number
[2810880-82-9]
UNSPSC
12352005
Target
MAP4K
Related Pathways
MAPK/ERK Pathway
Field of Research
Cancer
Smiles
FC1=CC=CC(OC)=C1C2=CC3=C(C=NN3C4=CC=CC(N5CC6N(C(CC6)C5)C)=N4)C=N2
Molecular Formula
C25H25FN6O
Molecular Weight
444.50
References & Citations
[1]Yu EC, et al. Identification of Potent Reverse Indazole Inhibitors for HPK1. ACS Med Chem Lett. 2021 Mar 1;12 (3) :459-466.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MAP4K1/HPK1
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
