C3001a

C3001a is a selective TREK-1 and TREK-2 channel activator with EC50 values of 12.81 μM and 11.31 μM, respectively. C3001a does not affect other two-pore domain K+ (K2P) channels. C3001a binds to the cryptic binding site formed by P1 and TM4 in TREK-1. C3001a can be used for the study of pain and pancreatitis[1].

Product Specifications

CAS Number

2415154-29-7

UNSPSC

12352005

Target

Potassium Channel

Related Pathways

Membrane Transporter/Ion Channel

Field of Research

Neurological Disease; Inflammation/Immunology

Smiles

O=C([C@@H]1C[C@H](C(NC2=CC=C(C3=NC4=CC=C(C)C=C4S3)C=C2)=O)CC1)O

Molecular Formula

C21H20N2O3S

Molecular Weight

380.46

References & Citations

[1]Qiu Y, et al. TREK Channel Family Activator with a Well-Defined Structure-Activation Relationship for Pain and Neurogenic Inflammation. J Med Chem. 2020 Apr 9;63 (7) :3665-3677.