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NCGC1481

NCGC1481 is an inhibitor of FLT3, IRAK1, and IRAK4, with IC50 values of FLT3 inhibitors and has antileukemic activity[1].

Product Specifications

CAS Number

2193085-94-6

UNSPSC

12352005

Target

FLT3; IRAK

Related Pathways

Immunology/Inflammation; Protein Tyrosine Kinase/RTK

Field of Research

Cancer

Smiles

CN1N=CC(C2=CN3C(C=C2OC)=NC=C3C4=CC=CC(NC5CNCC5)=N4)=C1

Molecular Formula

C21H23N7O

Molecular Weight

389.45

References & Citations

[1]Melgar K, et al. Overcoming adaptive therapy resistance in AML by targeting immune response pathways. Sci Transl Med. 2019 Sep 4;11 (508) :eaaw8828.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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