NCGC1481
NCGC1481 is an inhibitor of FLT3, IRAK1, and IRAK4, with IC50 values of FLT3 inhibitors and has antileukemic activity[1].
Product Specifications
CAS Number
[2193085-94-6]
UNSPSC
12352005
Target
FLT3; IRAK
Related Pathways
Immunology/Inflammation; Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Smiles
CN1N=CC(C2=CN3C(C=C2OC)=NC=C3C4=CC=CC(NC5CNCC5)=N4)=C1
Molecular Formula
C21H23N7O
Molecular Weight
389.45
References & Citations
[1]Melgar K, et al. Overcoming adaptive therapy resistance in AML by targeting immune response pathways. Sci Transl Med. 2019 Sep 4;11 (508) :eaaw8828.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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