VNPP433-3β (dihydrochloride)
VNPP433-3β (Galeterone 3β-imidazole) dihydrochloride is an orally active molecular glue degrader, which degrades androgen receptor (AR) and its splice variants (AR-Vs) and MAP kinase-interacting serine/threonine protein kinase Mnk1/2. VNPP433-3β dihydrochloride induces cell apoptosis. VNPP433-3β dihydrochloride inhibits tumor growth in the CWR22Rv1 xenograft mouse model. VNPP433-3β dihydrochloride can be used for the study of castration resistant prostate cancer (CRPC) and pancreatic ductal adenocarcinoma (PDAC) [1].
Product Specifications
CAS Number
[3026905-92-7]
Product Name Alternative
Galeterone 3β-imidazole (dihydrochloride)
UNSPSC
12352005
Target
Androgen Receptor; Apoptosis; MNK; Molecular Glues
Related Pathways
Apoptosis; MAPK/ERK Pathway; PROTAC; Vitamin D Related/Nuclear Receptor
Field of Research
Cancer
Smiles
C[C@@]12[C@](CC=C2N3C4=CC=CC=C4N=C3)([H])[C@@]5([H])[C@]([C@@]6(C(C[C@@H](N7C=CN=C7)CC6)=CC5)C)([H])CC1.Cl.Cl
Molecular Formula
C29H36Cl2N4
Molecular Weight
511.53
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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