1954U89

1954U89 is a potent, lipid-soluble and orally active inhibitor of dihydrofolate reductase (DHFR) . 1954U89 exhibits anticancer activity[1][2].

Product Specifications

CAS Number

[150057-49-1]

UNSPSC

12352005

Target

Dihydrofolate reductase (DHFR)

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Smiles

CC(N1C(CC)CC)=CC2=C1C=CC3=NC(N)=NC(N)=C23

Molecular Formula

C16H21N5

Molecular Weight

283.37

References & Citations

[1]Chen J C, et al. QSAR Studies on a Series of 7, 8‐Dialkyl‐1, 3‐diaminopyrrolo‐[3, 2‐f] quinazolines with Anticancer Activity[J]. Chinese Journal of Chemistry, 2006, 24 (11) : 1531-1537.|[2]Studenberg SD, et al. The pharmacokinetics of 1954U89, 1,3-diamino-7- (1-ethylpropyl) -8-methyl-7H-pyrrolo- (3,2-f) quinazoline, in dogs and rats after intravenous and oral administration. Biopharm Drug Dispos. 1997 Jul;18 (5) :433-42.