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(Rac) -AAA

(Rac) -AAA is the racemate of AAA. (Rac) -AAA is an antagonist of 20-HETE receptor. (Rac) -AAA can increase the expression of GPR75 receptor in androgen-insensitive prostate cancer cells. (Rac) -AAA dose-dependently increases p38 phosphorylation. (Rac) -AAA induces a significant decrease in the phosphor-AKT signal in nuclei of cells. (Rac) -AAA mitigates the NF-κB signal in unstimulated cell nuclei. (Rac) -AAA can diminish the membrane associated signal intensity. (Rac) -AAA decreases the FAK phosphorylation induced by 20-HETE[1].

Product Specifications

CAS Number

[3055022-23-3]

UNSPSC

12352211

Target

Cytochrome P450; FAK; Orphan GPCR; p38 MAPK

Related Pathways

GPCR/G Protein; MAPK/ERK Pathway; Metabolic Enzyme/Protease; Protein Tyrosine Kinase/RTK

Field of Research

Cancer

Smiles

O=C(C(NC(CCCC/C=C\CCCCCCC/C=C\CCCCO)=O)CC(O[Na])=O)O[Na]

Molecular Formula

C24H39NNa2O6

Molecular Weight

483.55

References & Citations

[1]Cárdenas, S., et al., (2020) . GPR75 receptor mediates 20-HETE-signaling and metastatic features of androgen-insensitive prostate cancer cells. Biochimica et biophysica acta. Molecular and cell biology of lipids, 1865 (2), 158573.

Shipping Conditions

Room temperature

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-160187A/

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Curated Selection

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