Patrinoside aglucone

Patrinoside aglucone (Compound 8) is an iridoid glucoside that can be isolated from the Valeriana tuberosa. Patrinoside aglucone has potent anticancer activity with G2/M phase tumor cell cycle arrest and apoptosis induction. Patrinoside aglucone also significantly inhibits the proliferation of cancer stem cells (such as MDA-MB-231 and U-251MG cells) . Patrinoside aglucone has great anti-inflammatory activity by inhibiting NO release (IC50: 43.44 μM) and significantly reduces the level of TNF-α, IL-1β, IL-6, PGE2 and COX-2[1][2].

Product Specifications

CAS Number

[76319-15-8]

Product Name Alternative

Patrinoside aglycone

UNSPSC

12352005

Target

Apoptosis; COX; Interleukin Related; NO Synthase; PGE synthase; TNF Receptor

Related Pathways

Apoptosis; Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Inflammation/Immunology

Smiles

CC(C)CC(O[C@H]1[C@@]2([H])[C@@](C[C@@H]([C@@H]2CO)O)([H])C(CO)=CO1)=O

Molecular Formula

C15H24O6

Molecular Weight

300.35

References & Citations

[1]Çelik C, et al. Exploring the anti-inflammatory and cytotoxic effects of Valeriana tuberosa L. constituents: Integrating in vitro and in silico studies. Fitoterapia. 2025 Jul;184:106604. |[2]Yoshikawa H, et al. Anti-Proliferative Effects of Iridoids from Valeriana fauriei on Cancer Stem Cells. Int J Mol Sci. 2022 Nov 17;23 (22) :14206.