Coumaperine
Coumaperine is an amide alkaloid. Coumaperine can be extracted from white piper. Coumaperine inhibits NF-κB. Coumaperine derivatives exhibit anticancer activity against non-small cell lung cancer and Hodgkin's lymphoma. Coumaperine derivatives have antibacterial activity[1][2].
Product Specifications
CAS Number
76733-91-0
UNSPSC
12352005
Target
Drug Intermediate; NF-κB
Related Pathways
NF-κB; Others
Field of Research
Cancer; Infection; Inflammation/Immunology
Smiles
OC(C=C1)=CC=C1/C=C/C=C/C(N2CCCCC2)=O
Molecular Formula
C16H19NO2
Molecular Weight
257.33
References & Citations
[1]Nandakumar N, et al. Synthesis of coumaperine derivatives: Their NF-κB inhibitory effect, inhibition of cell migration and their cytotoxic activity. Eur J Med Chem. 2017 Jan 5;125:1076-1087. |[2]Kadosh Y, et al. Quorum Sensing and NF-κB Inhibition of Synthetic Coumaperine Derivatives from Piper nigrum. Molecules. 2021 Apr 15;26 (8) :2293.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported
Frequently Asked Questions
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