Coumaperine

Coumaperine is an amide alkaloid. Coumaperine can be extracted from white piper. Coumaperine inhibits NF-κB. Coumaperine derivatives exhibit anticancer activity against non-small cell lung cancer and Hodgkin's lymphoma. Coumaperine derivatives have antibacterial activity[1][2].

Product Specifications

CAS Number

[76733-91-0]

UNSPSC

12352005

Target

Drug Intermediate; NF-κB

Related Pathways

NF-κB; Others

Field of Research

Cancer; Infection; Inflammation/Immunology

Smiles

OC(C=C1)=CC=C1/C=C/C=C/C(N2CCCCC2)=O

Molecular Formula

C16H19NO2

Molecular Weight

257.33

References & Citations

[1]Nandakumar N, et al. Synthesis of coumaperine derivatives: Their NF-κB inhibitory effect, inhibition of cell migration and their cytotoxic activity. Eur J Med Chem. 2017 Jan 5;125:1076-1087. |[2]Kadosh Y, et al. Quorum Sensing and NF-κB Inhibition of Synthetic Coumaperine Derivatives from Piper nigrum. Molecules. 2021 Apr 15;26 (8) :2293.