P38α inhibitor 6

P38α inhibitor 6 (compound 19) is a p38α inhibitor with the IC50 of 0.68 μM. p38α inhibitor 6 induces cell apoptosis and arrests cell cycle at G0 and G2/M phase. p38α inhibitor 6 decreases the TNF-α concentration as well as increased the expression of tumor suppressor gene p53, Bax/BCL-2 ratio and caspase 3/7[1].

Product Specifications

UNSPSC

12352005

Target

Apoptosis; Bcl-2 Family; Caspase; MDM-2/p53; p38 MAPK

Related Pathways

Apoptosis; MAPK/ERK Pathway

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Smiles

BrC1=CC=CC(N2C(N=CN=C3NC4=CC=C(C(NC5=CC=C(C)C=C5)=O)C=C4)=C3C=N2)=C1

Molecular Formula

C25H19BrN6O

Molecular Weight

499.36

References & Citations

[1]Ewieda SY, et al. Design, synthesis, and cytotoxicity screening of novel pyrazolopyrimidines over renal cell carcinoma (UO-31 cells) as p38α inhibitors, and apoptotic cells inducing activities. Eur J Med Chem. 2025 Jan 5;281:117005.