PKMYT1-IN-7
PKMYT1-IN-7 (compound 7) is an orally active PKMYT1 inhibitor with IC50 values of 1.6 nM and 0.06 μM against of PKMYT1 and pCDK1, respectively. PKMYT1-IN-7 suppresses the phosphorylation of CDK1 at T14 and Y15. PKMYT1-IN-7 shows anticancer activity both [1].
Product Specifications
CAS Number
2986404-30-0
UNSPSC
12352005
Target
CDK; Wee1
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Smiles
O=C(C1=C(N)N(C2=C(C)C=CC(O)=C2C)C(N=C(C)N3CF)=C1C3=O)N
Molecular Formula
C17H18FN5O3
Molecular Weight
359.35
References & Citations
[1]Wang C, et al. Discovery of pyrrolopyrimidinone derivatives as potent PKMYT1 inhibitors for the treatment of cancer. Eur J Med Chem. 2025 Jan 5;281:117025.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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