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PKMYT1-IN-7

PKMYT1-IN-7 (compound 7) is an orally active PKMYT1 inhibitor with IC50 values of 1.6 nM and 0.06 μM against of PKMYT1 and pCDK1, respectively. PKMYT1-IN-7 suppresses the phosphorylation of CDK1 at T14 and Y15. PKMYT1-IN-7 shows anticancer activity both [1].

Product Specifications

CAS Number

2986404-30-0

UNSPSC

12352005

Target

CDK; Wee1

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Smiles

O=C(C1=C(N)N(C2=C(C)C=CC(O)=C2C)C(N=C(C)N3CF)=C1C3=O)N

Molecular Formula

C17H18FN5O3

Molecular Weight

359.35

References & Citations

[1]Wang C, et al. Discovery of pyrrolopyrimidinone derivatives as potent PKMYT1 inhibitors for the treatment of cancer. Eur J Med Chem. 2025 Jan 5;281:117025.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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