Top1-IN-2
Top1-IN-2 (Compound 1a) is a topoisomerase 1 (Top1) inhibitor. Top1-IN-2 inhibits P-gp resistant tumor cells growth and induces cell apoptosis[1].
Product Specifications
UNSPSC
12352005
Target
Apoptosis; Topoisomerase
Related Pathways
Apoptosis; Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
N[C@@H](CC1)CN1C(C2=CC3=C(O)C4=C(C(O)=C3N2)C(C5=CC=CC=C5C4=O)=O)=O
Molecular Formula
C21H17N3O5
Molecular Weight
391.38
References & Citations
[1]Litvinova VA, et al. Naphthoindole-2-carboxamides as a lipophilic chemotype of hetarene-anthraquinones potent against P-gp resistant tumor cells. Eur J Med Chem. 2025 Jan 5;281:117013.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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