QI-18
QI-18 is a fibroblast activation protein (FAP) inhibitor with the IC50 of 0.50 nM, which is a 6.5-fold increase in potency over that of UAMC-1110. QI-18 can be used to synthesize high tumor selectivity and high dose radiotracers for the diagnosis and treatment of tumors[1].
Product Specifications
CAS Number
3093894-38-0
UNSPSC
12352005
Target
FAP
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Cancer
Smiles
OC(CNC([C@H](CC1=CC=C(C#N)C=C1)NC(COC2=CC=C(N=CC=C3C(NCC(N4CC(F)(F)C[C@H]4C#N)=O)=O)C3=C2)=O)=O)=O
Molecular Formula
C31H27F2N7O7
Molecular Weight
647.59
References & Citations
[1]Qiu X, et al. Rational modifications on N- (4-quinolinoyl) -Gly-2-cyanopyrrolidine to develop fibroblast activation protein-targeted radioligands with improved affinity and tumor uptake. Eur J Med Chem. 2025 Jan 5;281:117011.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
145551 100 µg
NK1.1 (CD161, CLEC5B, KLRB1, KLRB-1C, Klrb1c, Ly59, NKR, NKRP1, NKRP1A)
Sign In for Pricing
View Details ![Rabbit Polyclonal RAB8B Antibody [Alexa Fluor 700]](https://cdn.genprice.uk/genprice/uk/genprice2.webp)
NBP2-99626AF700 0.1 mL
Rabbit Polyclonal RAB8B Antibody [Alexa Fluor 700]
Sign In for Pricing
View Details 