QI-18
QI-18 is a fibroblast activation protein (FAP) inhibitor with the IC50 of 0.50 nM, which is a 6.5-fold increase in potency over that of UAMC-1110 (HY-100684, IC50 of 3.25 nM) . QI-18 can be used to synthesize high tumor selectivity and high dose radiotracers for the diagnosis and treatment of tumors[1].
Product Specifications
CAS Number
[3093894-38-0]
UNSPSC
12352005
Target
FAP
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Cancer
Smiles
OC(CNC([C@H](CC1=CC=C(C#N)C=C1)NC(COC2=CC=C(N=CC=C3C(NCC(N4CC(F)(F)C[C@H]4C#N)=O)=O)C3=C2)=O)=O)=O
Molecular Formula
C31H27F2N7O7
Molecular Weight
647.59
References & Citations
[1]Qiu X, et al. Rational modifications on N- (4-quinolinoyl) -Gly-2-cyanopyrrolidine to develop fibroblast activation protein-targeted radioligands with improved affinity and tumor uptake. Eur J Med Chem. 2025 Jan 5;281:117011.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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