HW161023
HW161023 (compound 5) is an orally active AP2-associated protein kinase 1 (AAK1) inhibitor with IC50 values of 5.4 nM and 11.9 μM aganist of AAK1and hERG, respectively. HW161023 inhibits the pain in chronic constriction injury of the sciatic nerve rat model[1].
Product Specifications
CAS Number
2920698-73-1
UNSPSC
12352005
Target
AAK1
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Smiles
CC(C)C[C@](C)(N)COC1=CC=C(C2=CC=NC(C(F)F)=C2)C3=NC=CN13
Molecular Formula
C20H24F2N4O
Molecular Weight
374.43
References & Citations
[1]Li J, et al. Discovery and evaluation of HW161023 as a potent and orally active AAK1 inhibitor. Bioorg Med Chem Lett. 2024 Dec 1;114:130012.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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