Neuroprotective agent 8

Neuroprotective agent 8 (compound AA-9) is an oral active neuroprotective agent by anti-oxidative stress and anti-inflammation. Neuroprotective agent 8 activates PGC-1α and inhibits NLRP3 in the rat MCAO ischemic stroke model[1].

Product Specifications

UNSPSC

12352100

Target

NOD-like Receptor (NLR) ; PGC-1α; Reactive Oxygen Species (ROS)

Related Pathways

Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Smiles

O=C(NC(CC1=CC=C(C)C=C1)C(OC)=O)CCCCC2CCSS2

Molecular Formula

C19H27NO3S2

Molecular Weight

381.55

References & Citations

[1]Zhu C, et al. Discovery of neuroprotective Agents: Potent, brain Penetrating, lipoic acid derivatives for the potential treatment of ischemic stroke by regulating oxidative stress and inflammation - a Preliminary study. Bioorg Chem. 2024 Jun;147:107339.