TCL1
TCL1 is a selective non-covalent inhibitor targeting the Pru domain of the Rpn-13 subunit in the 19S regulatory particle (19S RP) of the proteasome with an IC50 value of approximately 26 μM. TCL1 interferes with the recognition and transport of ubiquitinated proteins by Rpn-13, inhibits the degradation of proteins by the proteasome, and thus affects the balance of intracellular protein metabolism. TCL1 is promising for research of hematological malignancies[1][2][3].
Product Specifications
UNSPSC
12352005
Target
Proteasome
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Cancer
Smiles
O=C(CC1SC2=NN=C(CC3=CC=C(C=C3)Br)N2N=C1C4=CC=C(Cl)C=C4)O
Molecular Formula
C19H14BrClN4O2S
Molecular Weight
477.76
References & Citations
Shipping Conditions
Room temperature
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-159808/
Scientific Category
Reference compound1
Clinical Information
No Development Reported
CAS Number
[875165-39-2]
Available Sizes
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