Mal-Exatecan

Mal-Exatecan is a Mal (Maleimide) modified Exatecan (HY-13631), a DNA topoisomerase I (topoisomerase I) inhibitor[1].

Product Specifications

CAS Number

[3028213-52-4]

UNSPSC

12352203

Target

ADC Payload; Topoisomerase

Related Pathways

Antibody-drug Conjugate/ADC Related; Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Purity

99.39

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(C=CC1=O)N1CCCCCC(N[C@@H]2C3=C4C(C(N5C4)=CC([C@](O)(C(OC6)=O)CC)=C6C5=O)=NC7=CC(F)=C(C)C(CC2)=C73)=O

Molecular Formula

C34H33FN4O7

Molecular Weight

628.65

References & Citations

[1]Mitsui I, et al. A new water-soluble camptothecin derivative, DX-8951f, exhibits potent antitumor activity against human tumors in vitro and in vivo. Jpn J Cancer Res. 1995 Aug;86 (8) :776-82.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C (Powder, protect from light)

Scientific Category

ADC Related

Clinical Information

No Development Reported

Available Sizes

Curated Selection

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