FAP6-19

FAP6-19 is a fibroblast activation protein (FAP) targeting radioligand with a Kd of 18.2 nM. FAP6-19 selectively delivers therapeutic radioactive nuclides (such as 177Lu) to the tumor site by targeting the overexpressed FAP protein in the tumor microenvironment, achieving precise killing of cancer cells while minimizing radiation damage to healthy tissues. FAP6-19 exhibits extremely high total cellular uptake and good intracellular retention ability in HT1080 cells. After being labeled with 111In, FAP6-19 produced extremely high tumor/kidney and tumor/liver dose ratios in the mouse model with 4T1 tumors. FAP6-19 can be used in the research of solid tumors expressing FAP.

Product Specifications

CAS Number

[3095069-75-0]

UNSPSC

12352209

Target

FAP

Related Pathways

Immunology/Inflammation

Applications

Cancer-programmed cell death

Field of Research

Cancer

Smiles

O=C(NCCCC[C@H](NC(C1=CC=C(CNC(CCCC2=CC=C(I)C=C2)=O)C=C1)=O)C(N3CCN(CC4=CC=CC5=C4CN(C(C[C@H]6C(N[C@H](C(N7[C@H](C#N)CC(F)(F)C7)=O)C6)=O)=O)C5)CC3)=O)CN8CCN(CC(O)=O)CCN(CC(O)=O)CCN(CC(O)=O)CC8

Molecular Formula

C65H84F2IN13O13

Molecular Weight

1420.34

References & Citations

[1]Lindeman SD, et al. FAP Radioligand Linker Optimization Improves Tumor Dose and Tumor-to-Healthy Organ Ratios in 4T1 Syngeneic Model. J Med Chem. 2024 Jul 25;67 (14) :11827-11840.