MCL1020

MCL1020 is a CHK1 inhibitor with an IC50 of 1.61 μM. MCL1020 properly occupies the ATP pocket by interacting with a diverse range of the sites of CHK1 kinase. MCL1020 can be used for the study of hematologic malignancies[1].

Product Specifications

CAS Number

[2309309-69-9]

UNSPSC

12352005

Target

Checkpoint Kinase (Chk)

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-Kinase/protease

Field of Research

Cancer; Cardiovascular Disease

Smiles

N#CC1=NC=C(NC2=NC=C(C3=CC=CC=C3)C=N2)C=C1

Molecular Formula

C16H11N5

Molecular Weight

273.29

References & Citations

[1]Tong L, et al. Discovery of (R) -5- ((5- (1-methyl-1H-pyrazol-4-yl) -4- (methylamino) pyrimidin-2-yl) amino) -3- (piperidin-3-yloxy) picolinonitrile, a novel CHK1 inhibitor for hematologic malignancies. Eur J Med Chem. 2019 Jul 1;173:44-62.