(1S,2S,3R) -PLX-4545
(1S,2S,3R) -PLX-4545 is the (1S,2S,3R) enantiomer of PLX-4545 (HY-159647) . PLX-4545 is an orally active and selective cereblon-based molecular glue degrader of IKZF2 (zinc finger transcription factor Helios) . PLX-4545 can reprogram immunosuppressive regulatory T cells into pro-inflammatory effector T cells, thereby enhancing anti-tumor immune responses[1].
Product Specifications
CAS Number
[2892066-42-9]
UNSPSC
12352005
Target
IKZF Family; Molecular Glues
Related Pathways
Immunology/Inflammation; PROTAC
Field of Research
Cancer
Purity
91.78
Smiles
O=C([C@H](N(CC1=C2C=CC(O[C@@H]3[C@@H](N4CC(C5=CC=CC=C5)C4)CCCC3)=C1)C2=O)CC6)NC6=O
Molecular Formula
C28H31N3O4
Molecular Weight
473.56
References & Citations
[1]Huang Y, et al. PLX-4545, a selective IKZF2 degrader, reprograms suppressive Tregs leading to tumor growth inhibition and combination benefit with immune checkpoint therapy[J]. Cancer Research, 2025, 85 (8_Supplement_1) : 6380-6380.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
IKZF2
Curated Selection
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