(1S,2S,3R) -PLX-4545

(1S,2S,3R) -PLX-4545 is the (1S,2S,3R) enantiomer of PLX-4545 (HY-159647) . PLX-4545 is an orally active and selective cereblon-based molecular glue degrader of IKZF2 (zinc finger transcription factor Helios) . PLX-4545 can reprogram immunosuppressive regulatory T cells into pro-inflammatory effector T cells, thereby enhancing anti-tumor immune responses[1].

Product Specifications

CAS Number

[2892066-42-9]

UNSPSC

12352005

Target

IKZF Family; Molecular Glues

Related Pathways

Immunology/Inflammation; PROTAC

Field of Research

Cancer

Purity

91.78

Smiles

O=C([C@H](N(CC1=C2C=CC(O[C@@H]3[C@@H](N4CC(C5=CC=CC=C5)C4)CCCC3)=C1)C2=O)CC6)NC6=O

Molecular Formula

C28H31N3O4

Molecular Weight

473.56

References & Citations

[1]Huang Y, et al. PLX-4545, a selective IKZF2 degrader, reprograms suppressive Tregs leading to tumor growth inhibition and combination benefit with immune checkpoint therapy[J]. Cancer Research, 2025, 85 (8_Supplement_1) : 6380-6380.