(S, S) -PLX-4545
(S, S) -PLX-4545 (Compound I) is an orally active and cereblon-based molecular glue degrader of IKZF2 (zinc finger transcription factor Helios) . (S, S) -PLX-4545 can be used for the study of IKZF2-mediated diseases or disorders, such as proliferative diseases or disorders and/or cancer[1].
Product Specifications
CAS Number
[2892065-49-3]
UNSPSC
12352005
Target
IKZF Family; Molecular Glues
Related Pathways
Immunology/Inflammation; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Purity
96.09
Smiles
O=C1CCC(C(N1)=O)N2CC3=C(C2=O)C=CC(O[C@H]4CCCC[C@@H]4N5CC(C5)C6=CC=CC=C6)=C3
Molecular Formula
C28H31N3O4
Molecular Weight
473.56
References & Citations
[1]Pengyu YANG, et al. Salts and solid forms of compounds that modulate ikzf2. WO2025024823A1.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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