PWT-33597
PWT-33597 (VDC-597) is a dual inhibitor of PI3Kα and mTOR, which can effectively block the signaling downstream of PI3K and mTOR. PWT-33597 is capable of inducing tumor cell apoptosis and inhibiting tumor growth. PWT-33597 has anti-tumor activity and can be used in the research of tumors such as renal cell carcinoma[1].
Product Specifications
CAS Number
1246203-36-0
Product Name Alternative
VDC-597; SN33597
UNSPSC
12352005
Target
Apoptosis; mTOR; PI3K
Related Pathways
Apoptosis; PI3K/Akt/mTOR
Field of Research
Cancer
Smiles
CN(CCS(=O)(NC1=CC=C(C2=NC(N3C4=CC=CC(OC)=C4N=C3C(F)F)=NC(N5CCOCC5)=N2)C=C1)=O)C.CS(O)(=O)=O
Molecular Formula
C27H34F2N8O7S2
Molecular Weight
684.74
References & Citations
[1]O'Farrell M, et al. The PI3K/mTOR inhibitor PWT33597 regresses 786-0 renal xenografts. Cancer Research, 2012, 72 (8_Supplement) : 3737-3737.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Launched
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
BNC400225-500 1x 500 µL
Major Vault Protein (MVP) (1032), CF640R conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC040158-100 1x 100 µL
Cytokeratin 17 (E3), CF405S conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC401820-500 1x 500 µL
Ep-CAM / CD326 (Epithelial Marker) (rVU-1D9), CF640R conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC472465-100 1x 100 µL
Ki-67 (Proliferating Cell Marker) (MKI67/2465), CF647 conjugate, 0.1mg/mL
Sign In for Pricing
View Details 