PWT-33597 (free base)
PWT-33597 (VDC-597) free base is a dual inhibitor of PI3Kα and mTOR, which can effectively block the signaling downstream of PI3K and mTOR. PWT-33597 free base is capable of inducing tumor cell apoptosis and inhibiting tumor growth. PWT-33597 free base has anti-tumor activity and can be used in the research of tumors such as renal cell carcinoma[1].
Product Specifications
CAS Number
[1246203-32-6]
Product Name Alternative
VDC-597 (free base)
UNSPSC
12352005
Target
Apoptosis; mTOR; PI3K
Related Pathways
Apoptosis; PI3K/Akt/mTOR
Field of Research
Cancer
Smiles
CN(CCS(=O)(NC1=CC=C(C2=NC(N3C4=CC=CC(OC)=C4N=C3C(F)F)=NC(N5CCOCC5)=N2)C=C1)=O)C
Molecular Formula
C26H30F2N8O4S
Molecular Weight
588.63
References & Citations
[1]O'Farrell M, et al. The PI3K/mTOR inhibitor PWT33597 regresses 786-0 renal xenografts. Cancer Research, 2012, 72 (8_Supplement) : 3737-3737.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Launched
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