YK-8S

YK-8S is a dual-targeted K-Ras (G12D/G12C) covalent inhibitor. YK-8S shows no significant binding to wild-type K-Ras and other mutants (G12R, G13D, Q61R/K) . YK-8S exhibits anti-proliferative activity against H358 (G12C) and AGS (G12D) cells. YK-8S inhibits the phosphorylation of p-AKT/p-ERK in BaF3/G12D and G12C cells. YK-8S can be used for pancreatic cancer, colorectal cancer and other tumors with high incidence of G12D[1].

Product Specifications

CAS Number

[3060515-08-1]

UNSPSC

12352005

Target

Akt; ERK; Ras

Related Pathways

GPCR/G Protein; MAPK/ERK Pathway; PI3K/Akt/mTOR; Stem Cell/Wnt

Field of Research

Cancer

Purity

87.47

Smiles

FC1=C(C2=C(C=C1)C=CC=C2C3=C(C4=C(C=N3)C(N5CCN(CC5)C([C@H]6OC6)=O)=NC(OC[C@]78C[C@H](CN7CCC8)F)=N4)F)C#C

Molecular Formula

C34H31F3N6O3

Molecular Weight

628.64

References & Citations

[1]Yu Z, et al. Simultaneous Covalent Modification of K-Ras (G12D) and K-Ras (G12C) with Tunable Oxirane Electrophiles. J Am Chem Soc. 2023 Sep 20;145 (37) :20403-20411.