FASN-IN-7

FASN-IN-7 is a potent and orally active inhibitor of human Fatty Acid Synthase (FASN) . FASN-IN-7 shows enzyme inhibition on full length FASN and the FASN KR domain with IC50 values of 28 and 54 nM. FASN-IN-7 effectively inhibits proliferation of multiple cancer cell types. FASN-IN-7 increases malonyl-CoA levels and decreases palmitate levels in tumor tissues[1].

Product Specifications

CAS Number

[1579514-16-1]

UNSPSC

12352005

Target

Fatty Acid Synthase (FASN)

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Smiles

O=C1N(C[C@H]2CN(C(C3CC3)=O)CC2)C(C4=CC=C(C5=CC=C(C6=CN(C)N=C6)C=C5)C=C4)=NC71CC7

Molecular Formula

C30H31N5O2

Molecular Weight

493.60

References & Citations

[1]Lu T, et al. Design and synthesis of a series of bioavailable fatty acid synthase (FASN) KR domain inhibitors for cancer therapy. Bioorg Med Chem Lett. 2018;28 (12) :2159-2164.