FASN-IN-7
FASN-IN-7 is a potent and orally active inhibitor of human Fatty Acid Synthase (FASN) . FASN-IN-7 shows enzyme inhibition on full length FASN and the FASN KR domain with IC50 values of 28 and 54 nM. FASN-IN-7 effectively inhibits proliferation of multiple cancer cell types. FASN-IN-7 increases malonyl-CoA levels and decreases palmitate levels in tumor tissues[1].
Product Specifications
CAS Number
[1579514-16-1]
UNSPSC
12352005
Target
Fatty Acid Synthase (FASN)
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
O=C1N(C[C@H]2CN(C(C3CC3)=O)CC2)C(C4=CC=C(C5=CC=C(C6=CN(C)N=C6)C=C5)C=C4)=NC71CC7
Molecular Formula
C30H31N5O2
Molecular Weight
493.60
References & Citations
[1]Lu T, et al. Design and synthesis of a series of bioavailable fatty acid synthase (FASN) KR domain inhibitors for cancer therapy. Bioorg Med Chem Lett. 2018;28 (12) :2159-2164.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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